JMCB Symposium 2018: Looking into
Complex Diseases

JMCB Symposium 2018: Looking into Complex Diseases

June 8-10, 2018  Shanghai, China

June 8-10, 2018
 Shanghai, China


June 8, 2018 (Friday)

16:00-17:40 Opening & Keynote
16:00-16:10 Opening Remarks by Jiarui Wu
16:10-16:55 Stephen Kowalczykowski University of California, Davis, USA 
Title: Molecular functions of BRCA and RAD51 paralogs in homologous recombination
16:55-17:40 Mingjie Zhang Hong Kong University of Science & Technology, HK 
Title: DISC1 regulates neurogenesis via binding to Nde1/Ndel1 and ATF4

June 9, 2018 (Saturday morning)

08:30-11:50 Cocurrent Sessions I & II

08:30-11:50 Concurrent Session I
L Building Lecture Hall
Molecular Systems Biology in Complex Diseases 
Chaired by Jiarui Wu & Luonan Chen
08:30-08:55 Paul Kwong-Hang Tam The University of Hong Kong, HK
Title: Pluripotent stem cells to neural crest: the journey so far
08:55-09:20 Uttiya Basu Columbia University, USA 
Title: Noncoding RNA transcription regulation in B cell genomic integrity and organization
09:20-09:45 Sheng-Cai Lin Xiamen University, China
Title: The lysosomal AMPK actiation pathway—Glucose sensing and implications
09:45-10:10 Ralf Elvert Sanofi-Aventis Deutschland GmbH, Germany 
Title: The effect of GLP-1 and Glucagon receptor dual agonists on glucose and energy homeostasis: from mice to man
10:10-10:30 BREAK
10:30-10:55 Rong Zeng Shanghai Institute of Biochemistry and Cell Biology, CAS, China 
Title: Systems integration of multi-Omics data to evaluate physiological and pathological status 
10:55-11:20 Yumiko Imai National Institute of Biomedical Innovation, Health and Nutrition, Japan 
Title: Dynamic changes in host nuclear system to influenza virus infection
11:20-11:35 Jiguang Wang Hong Kong University of Science and Technology, HK 
Title: Mutational landscape of secondary glioblastoma reveals MET as a moving target in brain cancer
11:35-11:50 Yong Wang Academy of Mathematics and Systems Science, CAS, China 
Title: Intepretating genetic variants by gene regulatory network 
08:30-11:45 Concurrent Session II
Y Building Lecture Hall
Cell Biology and Disease Modeling in Organoids  
Chaired by Xuebiao Yao & Haian Fu
08:30-08:55 Haian Fu Emory University, USA 
Title: High-throughput synthetic lethal screening with a genetically engineered 3D organoids system 
08:55-09:20 Shuibing Chen Weill Cornell Medical College, USA 
Title: Human pluripotent stem cell based disease modeling and drug discovery
09:20-09:45 Leo Price OcellO, The Netherlands 
Title: Screening and profiling of (immuno-)oncology therapeutics in primary and stem cell-derived human 3D tissues 
09:45-10:10 Dong Gao Shanghai Institute of Biochemistry and Cell Biology, CAS, China 
Title: Cancer organoids and targeted therapy 
10:10-10:30 BREAK
10:30-10:55 Geert Kops Hubrecht Institute (KNAW), UMC Utrecht, Netherlands 
Make no mistake: Chromosomal instability and genomic heterogeneity in intestinal cancer
10:55-11:20 Weihang Chai Washington State University, USA 
Title: Decoding replication stress-induced fragile site and telomere instability 
11:20-11:45 Pengyu Huang ShanghaiTech University, China 
Title: Regulation of liver regeneration by pericentral hepatocytes during chronic injuries

June 9, 2018 (Saturday afternoon)

13:30-17:30 Cocurrent Sessions III & IV

13:30-17:30 Concurrent Session III
L Building Lecture Hall
Genome Instability and DNA Damage in Aging and Cancer 
Chaired by Binghui Shen & Zhiyuan Shen 
13:30-14:00 Wei Yang NIDDK, National Institutes of Health, USA 
Title: Molecular and atomic organization of DNA replication, recombination and repair 
14:00-14:30 Shridar Ganesan Rutgers Cancer Institute of New Jersey, USA 
Title: Interpreting and acting upon DNA repair gene mutations in clinical grade sequencing data
14:30-15:00 Lee Zou Harvard Medical School, MGH Cancer Center, USA 
Title: New roles of ATR in suppressing genomic instability
15:00-15:20 Li Lan University of Pittsburgh, USA 
Title: Insights into oxidative DNA damage responses in coding region of genome 
15:20-15:40 BREAK
15:40-16:10 Junjie Chen The University of Texas MD Anderson Cancer Center, USA 
Title: Proteomic analysis of DNA damage response and tumorigenesis 
16:10-16:40 Lawrence Sowers The University of Texas Medical Branch, USA 
Title: How does inflammation drive mutagenesis in colorectal cancer? 
16:40-17:10 Guang Peng The University of Texas MD Anderson Cancer Center, USA 
Title: PARP inhibitors induce immunogenicity through transcriptome reprogramming independent of BRCAness 
17:10-17:30 Wenge Zhu George Washington University School of Medicine and Health Science, USA 
Title: High-throughput analyses to identify a novel mechanism regulating platinum drug resistance in ovarian cancer
13:30-17:30 Concurrent Session IV
Y Building Lecture Hall
Immunity in Health and Diseases 
Chaired by Alfred L.M. Bothwell & Bing Su
13:30-14:00 Alfred L. M. Bothwell Yale Medical School, USA
Title: Wnt to regulate immunity
14:00-14:30 Bing Su Shanghai Jiao Tong University School of Medicine, China
Title: Endocytic adaptor protein disabled homolog 2 (DAB2) function in inflammation
14:30-15:00 Sankar Ghosh Columbia University Medical Center, USA 
Title: Regulation of immunoparalysis during sepsis 
15:00-15:20 Qiang Zou Shanghai Jiao Tong University School of Medicine, China
Title: Cross-talk between ROS and Treg cell-mediated tumor immunosuppression
15:20-15:40 BREAK
15:40-16:10 Yisong Wan University of North Carolina, USA 
Title: The regulation of Th17 cell function and its implication in disease 
16:10-16:40 Hai Qi Tsinghua University School of Medicine, China 
Title: Cellular dynamics and interactions supporting the germinal center 
16:40-17:10 Tian Chi ShanghaiTech University, China
Title: A reversible mouse model yields therapeutic insights for a fatal autoimmune disease
17:10-17:30 Huabing Li Shanghai Jiao Tong University School of Medicine, China 
Title: RNA m6A modification in T cell differentiation and inflammation

June 10, 2018 (Sunday)

08:30-11:00 Keynote & Closing
L Building Lecture Hall
08:30-09:15 Wing Hung Wong Stanford University, USA
Title: From genome to EHR: Challenges and strategies
09:15-10:00 Chen Dong Tsinghua University School of Medicine, China 
Title: Control of T cell function in immunity, inflammation and cancer
10:00-10:15  Closing Remarks by Xuebiao Yao